Per quanto riguarda le complicanze della celiachia, è ormai dimostrato che la malattia diagnosticata tardivamente o non trattata correttamente per tutta la vita, è gravata da una mortalità superiore a quella della popolazione generale.
Sebbene la mortalità dei pazienti celiaci diagnosticati in età pediatrica, e da allora in rigorosa dieta aglutinata, non sia aumentata rispetto a quella della popolazione generale, la mortalità dei celiaci diagnosticati in età adulta è pressoché raddoppiata. In particolare è stato recentemente dimostrato che la mortalità è aumentata soprattutto in pazienti adulti diagnosticati dopo i 50 anni, nei pazienti con diagnosi tardiva rispetto all’esordio dei sintomi, nei pazienti con sintomi all’esordio di malattia celiaca classica e nei pazienti che non seguono correttamente la dieta priva di glutine.
In molti casi la causa di morte è rappresentata da una delle complicanze che i pazienti hanno nella prolungata esposizione al glutine (il linfoma intestinale a cellule T, la digiuno-ileite ulcerativa, il carcinoma dell’intestino tenue, la malattia celiaca refrattaria e la sprue collagenosica).
È necessario tuttavia sottolineare che, nella maggioranza dei pazienti, diagnosi precoce e rigorosa ed una dieta totalmente priva di glutine proteggono dall’insorgenaza di tali complicanze così come da un rischio di mortalità aumentato nonché alla riduzione dell’aspettativa di vita.
Bibliografia:
Holmes G.K.T. Malignancy in coeliac disease: effect of a gluten free-diet. Gut, 1989
Sitografia:
http://www.ncbi.nlm.nih.gov/pubmed
http://www.biomedcentral.com/
http://www.celiachia.it/home/HomePage.aspx#
http://www.salute.gov.it/
http://www.unigastro.it/
http://digestive.niddk.nih.gov/
http://www.celiac.nih.gov/
Immagine di copertina tratta da: http://www.sicurezzaalimentare.it
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